Marion Independent School District contains an area of 80.38 square miles located in Guadalupe County in South Central Texas. The District is located on State Highway 78, approximately three miles from I-H 10 and five miles from I-H 35. There are three municipalities within the boundaries of MISD: the cities of Marion, New Berlin and Santa Clara. It is approximately nine miles northeast of Randolph Air Force Base, nine miles southwest of Seguin, ten miles south of New Braunfels, and twenty-five miles northeast of San Antonio. The boundaries of the District adjoin the boundaries of Seguin, New Braunfels, Comal, LaVernia, East Central and Schertz-Cibolo-Universal City Independent School Districts.